A Staged Z-pinch (H.U. Rahman, F.J. Wessel, N. Rostoker, Phys. Rev. Lett. 74:714, 1995), configured for a 100 ns, 2 MJ implosion accelerator, is studied using the 2-1/2 D, radiation-MHD code, MACH2. The Z-pinch is configured as a cylindrical, high-atomic number plasma shell that implodes radially onto a co-axial, plasma target, for example: Xenon onto a 50:50 mixture of Deuterium-Tritium. During implosion a shock develops in the plasma liner, producing a conduction channel at the Xe/DT interface as the mass Xe accumulates, and preheating the DT target. During subsequent acceleration and compression the Xe/DT interface remains stable, even as the outer surface of the Xe shell develops RT instabilities. At peak implosion the simulated fusion-energy yield is 7.6 MJ, producing an energy gain of 3.8.