In 2007, clusters of severe coxsackievirus B1 (CVB1) infection occurred across the United States, and CVB1 became the most commonly reported enterovirus. The complete genome sequence of CVB1 isolated from an infant (CVB1-Chi07) was examined and found to be divergent from the Conn5 reference strain, with 80% and 96% similarities at the nucleotide and amino acid levels, respectively.

We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.