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Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release.

  • Author(s): Aryal, Santosh
  • Hu, Che-Ming J
  • Fang, Ronnie H
  • Dehaini, Diana
  • Carpenter, Cody
  • Zhang, Dong-Er
  • Zhang, Liangfang
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817102/
No data is associated with this publication.
Abstract

AIM: Polymeric nanoparticles (NPs) cloaked by red blood cell membrane (RBCm) confer the combined advantage of both long circulation lifetime and controlled drug release. The authors carried out studies to gain a better understanding of the drug loading, drug-release kinetics and cell-based efficacy of RBCm-cloaked NPs. MATERIALS & METHODS: Two strategies for loading doxorubicin into the RBCm-cloaked NPs were compared: physical encapsulation and chemical conjugation. In vitro efficacy was examined using the acute myeloid leukemia cell line, Kasumi-1. RESULTS: It was found that the chemical conjugation strategy resulted in a more sustained drug release profile, and that the RBCm cloak provided a barrier, retarding the outward diffusion of encapsulated drug molecules. It was also demonstrated that RBCm-cloaked NPs exhibit higher toxicity in comparison with free doxorubicin. CONCLUSION: These results indicate that the RBCm-cloaked NPs hold great promise to become a valuable drug-delivery platform for the treatment of various diseases such as blood cancers.

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