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The Implication of Substance P in the Development of Tendinopathy: A Case Control Study.

  • Author(s): Han, Soo-Hong;
  • Choi, Wonchul;
  • Song, Jiye;
  • Kim, Jaehee;
  • Lee, Seungyong;
  • Choi, Youngrak;
  • Byun, Seong-Eun;
  • Ahn, Taekeun;
  • Ahn, Heejung;
  • Ding, Catherine;
  • Baik, Lloyd;
  • Ward, Spencer;
  • Ting, Kang;
  • Lee, Soonchul
  • et al.
Abstract

It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and tendinopathy tendon were harvested from human and tenocytes were cultured individually. The expression levels of genes associated with tendinopathy were compared. Next, substance P was exogenously administered to the healthy tenocyte and the effect was evaluated. The results showed that tendinopathy tenocytes had higher levels of COL3A1, MMP1, COX2, SCX, ACTA2, and substance P gene expression compared to healthy tenocytes. Next, substance P treatment on the healthy tenocyte displayed similar changes to that of the tendinopathy tenocytes. These differences between the two groups were also determined by Western blot. Additionally, cells with substance P had the tendinopathy change morphologically although cellular proliferation was significantly higher compared to that of the control group. In conclusion, substance P enhanced cellular proliferation, but concomitantly increased immature collagen (type 3 collagen). Substance P plays a crucial role in tendinopathy development and could be a future therapeutic target for treatment.

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