Three-Dimensional Engineered Platforms for Disease Modeling
Published Web Location
https://doi.org/10.1007/978-3-032-30294-6_15
Abstract
Three-dimensional (3D) platforms, especially microphysiological systems (MPS), have become transformative tools for modeling human diseases with greater physiological relevance than traditional 2D cultures. Moreover, MPS technologies are being developed to complement animal models, accelerating translational success while mitigating ethical concerns. In this chapter, we summarize recent advances in the development of MPS for modeling muscle disorders, bone diseases, cartilage degeneration, gut physiology and microbiome interactions, and skin pathologies, as well as their applications in drug screening. These platforms integrate engineered hydrogels, microfluidic systems, organoids, and mechanical or biochemical cues to recapitulate native tissue architecture, cellular heterogeneity, immune interactions, and multicellular crosstalk. Finally, we discuss future directions for applying MPS in aging and age-related disease research, personalized medicine, and biomarker discovery.
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