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Single Nucleotide Polymorphisms (5p15.33, 6p22.1 and 15q25.1), Smoking and Lung Cancer Survival


Background: Genome-wide studies of single nucleotide polymorphisms (SNPs) reported associations between chromosomal regions (5p15.33, 6p22.1 and 15q25.1) and lung cancer susceptibility. However, there are few published studies of the relationship between SNPs at these chromosomal regions and survival of lung cancer. Method: Six hundred and eleven lung cancer patients were followed up with a median duration of 11 years. Nine SNPs were genotyped using TaqMan assay. Cox proportional hazards regression model was employed to investigate their association with lung cancer survival. We also explored potential interactions of selected SNPs' with smoking on survival. Results: Overall, a total of 406 deaths occurred during the follow-up period. In survival analysis, only rs4324798 on chromosome 6p22.1 was associated with survival of lung cancer in dominant model (aHR: 1.51, 95%CI=1.11, 2.07). The association was also observed in non-small cell lung cancer (aHR: 1.56, 95%CI=1.09, 2.23) and large cell lung cancer (aHR: 4.15, 95%CI=1.63, 10.52). Association of AG+AA of rs4324798 and lung cancer survival was found among smokers (aHR: 1.5, 95%CI: 1.1, 2.1), but not among nonsmokers (aHR: 3.5, 95%CI: 0.4, 29.4). Conclusion: We observed an association of rs4324798

(6p22.1) with survival of lung cancer patients. The association remained among NSCLC and LCC histological subtypes, and smokers, although small numbers in some strata suggest caution in the interpretation of these findings.

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