Cycloadditions of cyclohexynes and cyclopentyne.
- Author(s): Medina, Jose M;
- McMahon, Travis C;
- Jiménez-Osés, Gonzalo;
- Houk, KN;
- Garg, Neil K
- et al.
Published Web Locationhttps://doi.org/10.1021/ja508635v
We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model.