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Cycloadditions of cyclohexynes and cyclopentyne.

  • Author(s): Medina, Jose M
  • McMahon, Travis C
  • Jiménez-Osés, Gonzalo
  • Houk, KN
  • Garg, Neil K
  • et al.

Published Web Location

https://doi.org/10.1021/ja508635v
Abstract

We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model.

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