Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.
Published Web Locationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932135/pdf/nihms537551.pdf
The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E and F is described. These natural prodcuts feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subseqent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.