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Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.

  • Author(s): Brockway, Anthony J
  • Grove, Charles I
  • Mahoney, Maximillian E
  • Shaw, Jared T
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932135/pdf/nihms537551.pdf
No data is associated with this publication.
Abstract

The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E and F is described. These natural prodcuts feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subseqent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.

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