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Synthesis of the diaryl ether cores common to chrysophaentins A, E, and F

  • Author(s): Brockway, AJ
  • Grove, CI
  • Mahoney, ME
  • Shaw, JT
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932135/pdf/nihms537551.pdf
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Abstract

© 2015 Elsevier Ltd. All rights reserved. The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E, and F is described. These natural products feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subsequent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.

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