Synthesis of the diaryl ether cores common to chrysophaentins A, E, and F
- Author(s): Brockway, AJ
- Grove, CI
- Mahoney, ME
- Shaw, JT
- et al.
Published Web Locationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932135/pdf/nihms537551.pdf
© 2015 Elsevier Ltd. All rights reserved. The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E, and F is described. These natural products feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subsequent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.
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