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Open Access Publications from the University of California

Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.

  • Author(s): Wang, Charlene
  • Abdel-Mohsen, Mohamed
  • Strain, Matthew C
  • Lada, Steven M
  • Yukl, Steven
  • Cockerham, Leslie R
  • Pilcher, Christopher D
  • Hecht, Frederick M
  • Sinclair, Elizabeth
  • Liegler, Teri
  • Richman, Douglas D
  • Deeks, Steven G
  • Pillai, Satish K
  • et al.

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Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantly lower in CD4+ T cells from CCR5-Δ32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4+ T cells (r2=0.136; P=.002). Our findings suggest that curative strategies should further explore manipulation of CCR5.

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