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On-chip cytometry using plasmonic nanoparticle enhanced lensfree holography.

  • Author(s): Wei, Qingshan
  • McLeod, Euan
  • Qi, Hangfei
  • Wan, Zhe
  • Sun, Ren
  • Ozcan, Aydogan
  • et al.

Published Web Location

https://doi.org/10.1038/srep01699
Abstract

Computational microscopy tools, in particular lensfree on-chip imaging, provide a large field-of-view along with a long depth-of-field, which makes it feasible to rapidly analyze large volumes of specimen using a compact and light-weight on-chip imaging architecture. To bring molecular specificity to this high-throughput platform, here we demonstrate the use of plasmon-resonant metallic nanoparticles to automatically recognize different cell types based on their plasmon-enhanced lensfree holograms, detected and reconstructed over a large field-of-view of e.g., ~24 mm².

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