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Engineering the Mesoporous Silica Nanoparticles to Chelate to Metal Ions for Bioapplications

  • Author(s): Yu, Chia Jung
  • Advisor(s): Zink, Jeffrey I
  • et al.
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Abstract

This dissertation focuses on improving cancer therapies and imaging by utilizing non-harmful material such as metal ions to replace traditional cancer therapies. The three chapters of this dissertation are presented as follows: 1. In Vitro Delivery of Calcium Ions by Nanogated Mesoporous Silica Nanoparticles to Induce Cancer Cellular Apoptosis. 2. Enhanced Fenton Reaction for Reactive Oxygen Species Generation by Iron Ion-Loaded Mesoporous Silica Nanoparticles for Cancer Therapy. 3. Cellular uptake efficiency study of enhanced T1 relaxivity gadolinium loaded iminodiacetic acid modified mesoporous silica nanoparticle.

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This item is under embargo until September 4, 2020.