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Open Access Publications from the University of California

In vivo breath-hold 1H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence

  • Author(s): Hamilton, G
  • Middleton, MS
  • Hooker, JC
  • Haufe, WM
  • Forbang, NI
  • Allison, MA
  • Loomba, R
  • Sirlin, CB
  • et al.

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© 2015 Wiley Periodicals, Inc. Purpose: To examine the intra-examination repeatability of proton density fat fraction (PDFF) and T1 and T2 of liver water and fat as estimated by a novel multi-repetition time (TR)-echo time (TE) 1H magnetic resonance spectroscopy (MRS)-stimulated echo acquisition mode (STEAM) sequence that acquires 32 spectra for a range of TRs and TEs in single breath-hold. Materials and Methods: Sixty-seven subjects undergoing liver MRI examinations at 3T had three multi-TR-TE sequences acquired consecutively in a single session. This sequence was designed to allow accurate estimation of T1 and T2 of both water and fat, as well as PDFF, in a single breath-hold. A standard long-TR, multi-TE sequence was also acquired to allow comparison of estimated PDFF. Regression and interclass correlation (ICC) analyses were performed. Results: There was strong agreement between PDFF estimated by the multi-TR-TE and long-TR, multi-TE sequences (slope 0.997; intercept -0.03; R=0.997). The multi-TR-TE sequence had high repeatability for estimating PDFF (ICC=0.999), water T2 (ICC=0.920), water T1 (ICC=0.845), and fat T2 (ICC=0.760), and moderate repeatability for estimating fat T1 (ICC=0.556). Conclusion: A novel multi-TR-TE sequence can estimate PDFF and water and fat T1 and T2 in a single breath-hold. Refinement may be needed to improve repeatability for fat T1 estimation.

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