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A challenging diagnosis of penile sarcomatoid squamous cell carcinoma

  • Author(s): Zhang, Sophia
  • Khosravi, Hasan
  • Cardis, Michael
  • Jedrych, Jaroslaw
  • Ho, Jonhan
  • Bunimovich, Yuri
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

We report a patient with penile sarcomatoid squamous cell carcinoma (SCC) initially misdiagnosed as condyloma acuminatum. Sarcomatoid SCC is a rare, aggressive, biphasic cancer that often presents a diagnostic challenge and carries a poor prognosis, especially after a delay in diagnosis. Although sarcomatoid SCC may exhibit a broad range of clinical features, the expression of p63 and keratin 34?E12 is a common finding. Our case highlights the importance of accurate clinicopathologic correlation to facilitate a timely diagnosis and management of this rare and highly aggressive malignancy.

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