Skip to main content
eScholarship
Open Access Publications from the University of California

The contribution of asymptomatic Plasmodium infections to the transmission of malaria in Kayin state, Myanmar.

  • Author(s): Chaumeau, Victor
  • Kajeechiwa, Ladda
  • Fustec, Bénédicte
  • Landier, Jordi
  • Nyo, Saw Naw
  • Hsel, Saw Nay
  • Phatharakokordbun, Phabele
  • Kittiphanakun, Prapan
  • Nosten, Suphak
  • Thwin, May Myo
  • Tun, Saw Win
  • Wiladphaingern, Jacher
  • Cottrell, Gilles
  • Parker, Daniel M
  • Minh, Myo Chit
  • Kwansomboon, Nittpha
  • Metaane, Selma
  • Montazeau, Céline
  • Kunjanwong, Kitti
  • Sawasdichai, Sunisa
  • Andolina, Chiara
  • Ling, Clare
  • Haohankhunnatham, Warat
  • Christiensen, Peter
  • Wanyatip, Sunaree
  • Konghahong, Kamonchanok
  • Cerqueira, Dominique
  • Imwong, Mallika
  • Dondorp, Arjen M
  • Chareonviriyaphap, Theeraphap
  • White, Nicholas J
  • Nosten, François H
  • Corbel, Vincent
  • et al.
Abstract

The objective of mass antimalarial drug administration (MDA) is to eliminate malaria rapidly by eliminating the asymptomatic malaria parasite reservoirs and interrupting transmission. In the Greater Mekong Subregion, where artemisinin resistant P. falciparum is now widespread, MDA has been proposed as an elimination accelerator, but the contribution of asymptomatic infections to malaria transmission has been questioned. The impact of MDA on entomological indices has not been characterised previously. MDA was conducted in four villages in Kayin State (Myanmar). Malaria mosquito vectors were captured three months before, during and three months after MDA, and their Plasmodium infections were detected by PCR. The relationship between the entomological inoculation rate, the malaria prevalence in humans determined by ultra-sensitive PCR, and MDA was characterised by Generalized Estimating Equation regression. Plasmodium falciparum and P. vivax asymptomatic infections were cleared by MDA. The P. vivax entomological inoculation rate was reduced 12.5 fold (95%25CI= [1.6; 100]) but the reservoir of asymptomatic P. vivax reconstituted within three months presumably because of relapses. This was coincident with a 5.3-fold (95%25CI= [4.8; 6.0]) increase in the vector infection rate. Asymptomatic infections are a major source of malaria transmission in Southeast Asia.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item