Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
- Author(s): Arslan, Alan A
- Helzlsouer, Kathy J
- Kooperberg, Charles
- Shu, Xiao-Ou
- Steplowski, Emily
- Bueno-de-Mesquita, H Bas
- Fuchs, Charles S
- Gross, Myron D
- Jacobs, Eric J
- Lacroix, Andrea Z
- Petersen, Gloria M
- Stolzenberg-Solomon, Rachael Z
- Zheng, Wei
- Albanes, Demetrius
- Amundadottir, Laufey
- Bamlet, William R
- Barricarte, Aurelio
- Bingham, Sheila A
- Boeing, Heiner
- Boutron-Ruault, Marie-Christine
- Buring, Julie E
- Chanock, Stephen J
- Clipp, Sandra
- Gaziano, J Michael
- Giovannucci, Edward L
- Hankinson, Susan E
- Hartge, Patricia
- Hoover, Robert N
- Hunter, David J
- Hutchinson, Amy
- Jacobs, Kevin B
- Kraft, Peter
- Lynch, Shannon M
- Manjer, Jonas
- Manson, Joann E
- McTiernan, Anne
- McWilliams, Robert R
- Mendelsohn, Julie B
- Michaud, Dominique S
- Palli, Domenico
- Rohan, Thomas E
- Slimani, Nadia
- Thomas, Gilles
- Tjønneland, Anne
- Tobias, Geoffrey S
- Trichopoulos, Dimitrios
- Virtamo, Jarmo
- Wolpin, Brian M
- Yu, Kai
- Zeleniuch-Jacquotte, Anne
- Patel, Alpa V
- Pancreatic Cancer Cohort Consortium (PanScan)
- et al.
Published Web Location
http://10.0.3.233/archinternmed.2010.63Abstract
BACKGROUND:Obesity has been proposed as a risk factor for pancreatic cancer. METHODS:Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, > or = 35.0). Models were adjusted for potential confounders. RESULTS:In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; P(trend) < .001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; P(trend) < .03), and in women it was 1.34 (95% CI, 1.05-1.70; P(trend) = .01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; P(trend) = .003) but less so in men. CONCLUSIONS:These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
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