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Open Access Publications from the University of California

Chronic paracoccidioidmycosis in a woman with Crohn Disease

  • Author(s): Tavares dos Santos, Harim
  • Augusto Benevenuto de Andrade, Bruno
  • Fernandes, Darcy
  • Caxias Travassos, Daphine
  • Bufalino, Andreia
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

We report a rare case of chronic paracoccidioidomycosis(PCM) in a woman with Crohn disease in the setting oftreatment with azathioprine and mesalazine. Serumtests for antigens to Paracoccidioides brasiliensis,Histoplasma capsulatum, and Aspergillus fumigatuswere negative. An incisional biopsy of an oral lesionwith periodic acid-schiff and Grocott-methenaminesilverstains revealed chronic granulomatousinflammation with multinucleated giant cells withParacoccidioides brasiliensis within the cytoplasm,confirming the diagnosis of PCM.

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