Gender differences in melanoma prognostic factors
- Author(s): Farahi, Jessica M;
- Fazzari, Melissa;
- Braunberger, Taylor;
- Caravaglio, Joseph V;
- Kretowicz, Alexandra;
- Wells, Keith;
- Dellavalle, Robert P;
- Norris, David;
- Alkousakis, Theodore
- et al.
Published Web Locationhttps://doi.org/10.5070/D3244039352
Background: Although previous studies identify gender differences in melanoma, limited research on the phenomenon exists.Methods: In this retrospective chart review, 1,156 adults diagnosed with melanoma, between 2006-2016, at the University of Colorado were included. Breslow depth, mitotic rate, ulceration status, and location were extracted from charts between March and August 2016. Cochran-Armitage trend tests and cumulative logistic regression were used to examine the association between gender and Breslow depth, univariately and after adjusting for potential confounders.
Results: In univariate analysis, males were significantly more likely to present with lesions with higher Breslow depths (p for trend=0.005). In models adjusted for age, melanoma subtype, and location, males were marginally more likely to present with lesions with higher Breslow depths (cumulative OR: 1.261, 95% CI: 0.988-1.611, p=0.060). Males were also marginally more likely to present with lesions with higher mitotic rates, after further adjustments for all other prognostic factors (cumulative OR: 1.244, 95% CI: 0.979-1.580, p=0.074).
Limitations: This was a retrospective single-institution study.
Conclusion: Differences in mitotic rates among melanomas in males versus females, even after adjustments for all other prognostic factors, suggests that biological differences may contribute to the female prognosis advantage.