Skip to main content
eScholarship
Open Access Publications from the University of California

UCLA

UCLA Previously Published Works bannerUCLA

Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence

Abstract

Early-life adversity (ELA) exposure (e.g., trauma, abuse, neglect, or institutional care) is a precursor to poor physical and mental health outcomes and is implicated in 30% of adult mental illness. In recent decades, ELA research has increasingly focused on characterizing factors that confer resilience to ELA and on identifying opportunities for intervention. In this review, we describe recent behavioral and neurobiological resilience work that suggests that adolescence (a period marked by heightened plasticity, development of key neurobiological circuitry, and sensitivity to the social environment) may be a particularly opportune moment for ELA intervention. We review intrapersonal factors associated with resilience that become increasingly important during adolescence (specifically, reward processing, affective learning, and self-regulation) and describe the contextual factors (family, peers, and broader social environment) that modulate them. In addition, we describe how the onset of puberty interacts with each of these factors, and we explore recent findings that point to possible "pubertal recalibration" of ELA exposure as an opportunity for intervention. We conclude by describing considerations and future directions for resilience research in adolescents, with a focus on understanding developmental trajectories using dimensional and holistic models of resilience.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View