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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
- Chin, Randall M;
- Fu, Xudong;
- Pai, Melody Y;
- Vergnes, Laurent;
- Hwang, Heejun;
- Deng, Gang;
- Diep, Simon;
- Lomenick, Brett;
- Meli, Vijaykumar S;
- Monsalve, Gabriela C;
- Hu, Eileen;
- Whelan, Stephen A;
- Wang, Jennifer X;
- Jung, Gwanghyun;
- Solis, Gregory M;
- Fazlollahi, Farbod;
- Kaweeteerawat, Chitrada;
- Quach, Austin;
- Nili, Mahta;
- Krall, Abby S;
- Godwin, Hilary A;
- Chang, Helena R;
- Faull, Kym F;
- Guo, Feng;
- Jiang, Meisheng;
- Trauger, Sunia A;
- Saghatelian, Alan;
- Braas, Daniel;
- Christofk, Heather R;
- Clarke, Catherine F;
- Teitell, Michael A;
- Petrascheck, Michael;
- Reue, Karen;
- Jung, Michael E;
- Frand, Alison R;
- Huang, Jing
Published Web Location
https://doi.org/10.1038/nature13264Abstract
Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR).
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