Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation
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Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation

  • Author(s): Gordeuk, Victor R
  • Lovato, Laura
  • Barton, James C
  • Vitolins, Mara
  • McLaren, Gordon
  • Acton, Ronald T
  • McLaren, Christine
  • Harris, Emily L
  • Speechley, Mark
  • Eckfeldt, John H
  • Diaz, Sharmin
  • Sholinsky, Phyliss
  • Adams, Paul
  • et al.
Abstract

BACKGROUND:

HFEC282Y homozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals.

OBJECTIVE:

To determine whether dietary iron content influences iron stores in HFEC282Y homozygotes as assessed by serum ferritin concentration.

DESIGN:

Serum ferritin concentration was measured and a dietary iron questionnaire was completed as part of the evaluation of 213 HFEC282Y homozygotes who were identified through screening of >100,000 primary care patients at five HEmochromatosis and IRon Overload Screening (HEIRS) Study Field Centers in the United States and Canada.

RESULTS:

No significant relationships between serum ferritin concentration and dietary heme iron content, dietary nonheme iron content or reports of supplemental iron use were found.

CONCLUSION:

These results do not support recommending dietary heme or nonheme iron restrictions for HFEC282Y homozygotes diagnosed through screening in North America.

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