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Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury
- Rosenzweig, Ephron S;
- Courtine, Gregoire;
- Jindrich, Devin L;
- Brock, John H;
- Ferguson, Adam R;
- Strand, Sarah C;
- Nout, Yvette S;
- Roy, Roland R;
- Miller, Darren M;
- Beattie, Michael S;
- Havton, Leif A;
- Bresnahan, Jacqueline C;
- Edgerton, V Reggie;
- Tuszynski, Mark H
Published Web Location
https://doi.org/10.1038/nn.2691Abstract
Rosenzweig and colleagues show that incomplete cervical spinal cord injury in macaques triggers substantially greater sprouting of spared corticospinal axons below the lesion. The monkeys also recovered significant locomotor ability, correlating with the extent of anatomical 'repair'.
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