Skip to main content
eScholarship
Open Access Publications from the University of California

Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab

  • Author(s): Romero-Maté, Alberto
  • García-Donoso, Carmen
  • Hernández-Núñez, Almudena
  • Martínez-Morán, Cristina
  • Moreno-Torres, Amalia
  • Borbujo-Martínez, Jesús
  • et al.
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License
Abstract

We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Fortyeight months later stable improvement was achievedwithout side effects. Only nine patients with cutaneouslupus erythematosus (CLE) treated with ustekinumabhave been reported to date. Ustekinumab could be apromising alternative in severe and recalcitrant casesof CLE. Possibly, the Th17-inflammation pathway isplaying a role in these patients.

Main Content
Current View