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ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.

  • Author(s): Cedó, Lídia
  • García-León, Annabel
  • Baila-Rueda, Lucía
  • Santos, David
  • Grijalva, Victor
  • Martínez-Cignoni, Melanie Raquel
  • Carbó, José M
  • Metso, Jari
  • López-Vilaró, Laura
  • Zorzano, Antonio
  • Valledor, Annabel F
  • Cenarro, Ana
  • Jauhiainen, Matti
  • Lerma, Enrique
  • Fogelman, Alan M
  • Reddy, Srinivasa T
  • Escolà-Gil, Joan Carles
  • Blanco-Vaca, Francisco
  • et al.

Published Web Location

https://doi.org/10.1038/srep36387
Abstract

Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.

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