Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
- Author(s): Jacobs, Eric J
- Chanock, Stephen J
- Fuchs, Charles S
- Lacroix, Andrea
- McWilliams, Robert R
- Steplowski, Emily
- Stolzenberg-Solomon, Rachael Z
- Arslan, Alan A
- Bueno-de-Mesquita, H Bas
- Gross, Myron
- Helzlsouer, Kathy
- Petersen, Gloria
- Zheng, Wei
- Agalliu, Ilir
- Allen, Naomi E
- Amundadottir, Laufey
- Boutron-Ruault, Marie-Christine
- Buring, Julie E
- Canzian, Federico
- Clipp, Sandra
- Dorronsoro, Miren
- Gaziano, J Michael
- Giovannucci, Edward L
- Hankinson, Susan E
- Hartge, Patricia
- Hoover, Robert N
- Hunter, David J
- Jacobs, Kevin B
- Jenab, Mazda
- Kraft, Peter
- Kooperberg, Charles
- Lynch, Shannon M
- Sund, Malin
- Mendelsohn, Julie B
- Mouw, Tracy
- Newton, Christina C
- Overvad, Kim
- Palli, Domenico
- Peeters, Petra HM
- Rajkovic, Aleksandar
- Shu, Xiao-Ou
- Thomas, Gilles
- Tobias, Geoffrey S
- Trichopoulos, Dimitrios
- Virtamo, Jarmo
- Wactawski-Wende, Jean
- Wolpin, Brian M
- Yu, Kai
- Zeleniuch-Jacquotte, Anne
- et al.
Abstract
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
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