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Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

  • Author(s): Jacobs, Eric J
  • Chanock, Stephen J
  • Fuchs, Charles S
  • Lacroix, Andrea
  • McWilliams, Robert R
  • Steplowski, Emily
  • Stolzenberg-Solomon, Rachael Z
  • Arslan, Alan A
  • Bueno-de-Mesquita, H Bas
  • Gross, Myron
  • Helzlsouer, Kathy
  • Petersen, Gloria
  • Zheng, Wei
  • Agalliu, Ilir
  • Allen, Naomi E
  • Amundadottir, Laufey
  • Boutron-Ruault, Marie-Christine
  • Buring, Julie E
  • Canzian, Federico
  • Clipp, Sandra
  • Dorronsoro, Miren
  • Gaziano, J Michael
  • Giovannucci, Edward L
  • Hankinson, Susan E
  • Hartge, Patricia
  • Hoover, Robert N
  • Hunter, David J
  • Jacobs, Kevin B
  • Jenab, Mazda
  • Kraft, Peter
  • Kooperberg, Charles
  • Lynch, Shannon M
  • Sund, Malin
  • Mendelsohn, Julie B
  • Mouw, Tracy
  • Newton, Christina C
  • Overvad, Kim
  • Palli, Domenico
  • Peeters, Petra HM
  • Rajkovic, Aleksandar
  • Shu, Xiao-Ou
  • Thomas, Gilles
  • Tobias, Geoffrey S
  • Trichopoulos, Dimitrios
  • Virtamo, Jarmo
  • Wactawski-Wende, Jean
  • Wolpin, Brian M
  • Yu, Kai
  • Zeleniuch-Jacquotte, Anne
  • et al.

Published Web Location

http://10.0.3.234/ijc.25148
No data is associated with this publication.
Abstract

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

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