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Open Access Publications from the University of California

Multinucleate cell angiohistiocytoma: a case report and review of the literature.

  • Author(s): Applebaum, Danielle S
  • Shuja, Fareesa
  • Hicks, Lindsey
  • Cockerell, Clay
  • Hsu, Sylvia
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Multinucleate cell angiohistiocytoma (MCAH) is a rare, benign vascular proliferation.  Fewer than 80 cases have been reported to date, which may relate to under-recognition of this entity. Lesions are commonly asymptomatic and appear as erythematous to violaceous papules on the lower extremities and dorsal hands of middle-aged to elderly women. The characteristic histopathologic and immunohistochemical features of MCAH are essential for definitive diagnosis of MCAH. Multinucleate cell angiohistiocytoma follows a slowly progressive course, although spontaneous regression has been reported in rare cases. We present a case of MCAH to increase awareness and elucidate the characteristic clinical and histopathologic features of this disorder.

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