Medical Student Research Forum Posters

Background: Transdermal drug delivery (TDD) is a method used to deliver a therapy into systemic circulation across the skin. Transdermal therapeutic administration is common practice in response to chronic inflammatory skin disease. However, subtherapeutic outcomes are prevalent without known cause. This is largely due to inter- and intraindividual variability of drug absorption through the skin. It is known that the inherent skin membrane function poses unique challenges to effective systemic drug delivery. Diffusion, metabolism, and other skin biophysics profiles and their contributions to drug response have yet to be fully elucidated.

Problem: The use of computational and predictive modelling poses potential to assist drug developers and clinicians in determining the most effective drugs for a given patient with their unique biological profile. Given the intricacies of biological interplay, it is important to determine which biological factors are the most predictive for drug delivery efficacy.

Why this model?: This one compartment model is used to simply illustrate the relationship between varied simulated rate constants and drug concentrations of the drug donor and acceptor as it relates to time