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Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
- Howson, Joanna MM;
- Zhao, Wei;
- Barnes, Daniel R;
- Ho, Weang-Kee;
- Young, Robin;
- Paul, Dirk S;
- Waite, Lindsay L;
- Freitag, Daniel F;
- Fauman, Eric B;
- Salfati, Elias L;
- Sun, Benjamin B;
- Eicher, John D;
- Johnson, Andrew D;
- Sheu, Wayne HH;
- Nielsen, Sune F;
- Lin, Wei-Yu;
- Surendran, Praveen;
- Malarstig, Anders;
- Wilk, Jemma B;
- Tybjærg-Hansen, Anne;
- Rasmussen, Katrine L;
- Kamstrup, Pia R;
- Deloukas, Panos;
- Erdmann, Jeanette;
- Kathiresan, Sekar;
- Samani, Nilesh J;
- Schunkert, Heribert;
- Watkins, Hugh;
- Do, Ron;
- Rader, Daniel J;
- Johnson, Julie A;
- Hazen, Stanley L;
- Quyyumi, Arshed A;
- Spertus, John A;
- Pepine, Carl J;
- Franceschini, Nora;
- Justice, Anne;
- Reiner, Alex P;
- Buyske, Steven;
- Hindorff, Lucia A;
- Carty, Cara L;
- North, Kari E;
- Kooperberg, Charles;
- Boerwinkle, Eric;
- Young, Kristin;
- Graff, Mariaelisa;
- Peters, Ulrike;
- Absher, Devin;
- Hsiung, Chao A;
- Lee, Wen-Jane;
- Taylor, Kent D;
- Chen, Ying-Hsiang;
- Lee, I-Te;
- Guo, Xiuqing;
- Chung, Ren-Hua;
- Hung, Yi-Jen;
- Rotter, Jerome I;
- Juang, Jyh-Ming J;
- Quertermous, Thomas;
- Wang, Tzung-Dau;
- Rasheed, Asif;
- Frossard, Philippe;
- Alam, Dewan S;
- Majumder, Abdulla al Shafi;
- Di Angelantonio, Emanuele;
- Chowdhury, Rajiv;
- Chen, Yii-Der Ida;
- Nordestgaard, Børge G;
- Assimes, Themistocles L;
- Danesh, John;
- Butterworth, Adam S;
- Saleheen, Danish
Published Web Location
https://doi.org/10.1038/ng.3874Abstract
Joanna Howson and colleagues perform a genome-wide association study and meta-analysis for coronary artery disease in large, trans-ancestry cohorts. They identify 15 new loci and correlate these regions with cell-type-specific gene expression and plasma protein levels to find novel pathways and potential mechanisms of disease.
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