UC San Diego

The 1966 movie Fantastic Voyage captured the world's imagination, portraying a tiny submarine navigating through the human bloodstream and treating life- threatening medical conditions. My PhD research focuses on the synthetic nano/microscale machines to realize the Fantastic Voyage vision. Various biomedical and environmental areas would benefit from the developments of efficient fuel-free and fuel-driven nano/microscale machines. The polymer-based catalytic tubular microengine is synthesized using a template based electrodeposition method. The oxygen bubble propelled microengine harvests the energy from chemical fuels (such as H₂O₂) and displays very efficient propulsion. It can serve as an ideal platform for diverse biomedical and environmental applications. For example, lectin modified polyaniline based microengines can be used for selective bacteria (E. Coli) isolation from food, clinical and environmental samples; poly(3-aminophenylboronic acid)/Ni/Pt microengine itself provides the ̀built in' glucose recognition capability for 'on-the-fly' capture, transport and release of yeast cells. A series of micromotors which can be self- propelled in natural environments without additional chemical fuels are developed, holding great promise for in vivo biomedical applications : the polyaniline/zinc microrockets display effective autonomous motion in extreme acidic environments (such as human stomach); the Al-Ga/Ti based Janus micromotor can be propelled by the hydrogen bubbles generated from the rapid aluminum and water reaction; alkanethiols modified seawater-driven Mg Janus micromotors, which utilize macrogalvanic corrosion and chloride pitting corrosion processes, can be used for environmental oil remediation. Magnetically powered nanoswimmers have attracted considerable attention due to their great biocompatibility. A high-speed magnetically- propelled nanowire swimmer which mimics swimming microorganisms by exploiting the flexible nanowire as artificial flagella under rotating magnetic field is illustrated. New bioinspired microswimmers can also be prepared directly from isolated spiral vessels of plants, harnessing the intrinsic biological structures of nature. Potential applications of these cargo-towing nanoswimmers are demonstrated by the directed delivery of drug-loaded microparticles to HeLa cancer cells in biological media. With such innovations and developments, along with careful attention to key challenges and requirements, nano/ microscale motors are expected to have tremendous impact on diverse biomedical and environmental applications, providing unlimited opportunities limited only by one's imagination