Skip to main content
eScholarship
Open Access Publications from the University of California

UC Berkeley

UC Berkeley Previously Published Works bannerUC Berkeley

Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: Pooled results from two Chinese genome-wide association studies

  • Author(s): Wang, Z
  • Dai, J
  • Hu, N
  • Miao, X
  • Abnet, CC
  • Yang, M
  • Freedman, ND
  • Chen, J
  • Burdette, L
  • Zhu, X
  • Chung, CC
  • Ren, C
  • Dawsey, SM
  • Wang, M
  • Ding, T
  • Du, J
  • Gao, YT
  • Zhong, R
  • Giffen, C
  • Pan, W
  • Koh, WP
  • Dai, N
  • Liao, LM
  • Yan, C
  • Qiao, YL
  • Jiang, Y
  • Shu, XO
  • Chen, J
  • Wang, C
  • Ma, H
  • Su, H
  • Zhang, Z
  • Wang, L
  • Wu, C
  • Xiang, YB
  • Hu, Z
  • Yuan, JM
  • Xie, L
  • Zheng, W
  • Lin, D
  • Chanock, SJ
  • Shi, Y
  • Goldstein, AM
  • Jin, G
  • Taylor, PR
  • Shen, H
  • et al.

Published Web Location

http://doi.org/10.1136/gutjnl-2015-310612
No data is associated with this publication.
Abstract

© 2017, BMJ Publishing Group. All rights reserved. Objective: Although several genome-wide association studies (GWAS) of non-cardia gastric cancer have been published, more novel association signals could be exploited by combining individual studies together, which will further elucidate the genetic susceptibility of non-cardia gastric cancer. Design: We conducted a meta-analysis of two published Chinese GWAS studies (2031 non-cardia gastric cancer cases and 4970 cancer-free controls) and followed by genotyping of additional 3564 cases and 4637 controls in two stages. Results: The overall meta-analysis revealed two new association signals. The first was a novel locus at 5q14.3 and marked by rs7712641 (per-allele OR=0.84, 95% CI 0.80 to 0.88; p=1.21×10-11). This single-nucleotide polymorphism (SNP) marker maps to the intron of the long non-coding RNA, lnc-POLR3G-4 (XLOC-004464), which we observed has lower expression in non-cardia gastric tumour compared with matched normal tissue (Pwilcoxon signed-rank=7.20×10-4). We also identified a new signal at the 1q22 locus, rs80142782 (per-allele OR=0.62; 95% CI 0.56 to 0.69; p=1.71×10-19), which was independent of the previously reported SNP at the same locus, rs4072037 (per-allele OR=0.74; 95% CI 0.69 to 0.79; p=6.28×10-17). Analysis of the new SNP conditioned on the known SNP showed that the new SNP remained genome-wide significant (Pconditional=3.47×10-8). Interestingly, rs80142782 has a minor allele frequency of 0.05 in East Asians but is monomorphic in both European and African populations. Conclusion: These findings add new evidence for inherited genetic susceptibility to non-cardia gastric cancer and provide further clues to its aetiology in the Han Chinese population.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item