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Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis.

  • Author(s): Gebremariam, Teclegiorgis;
  • Alkhazraji, Sondus;
  • Gu, Yiyou;
  • Singh, Shakti;
  • Alqarihi, Abdullah;
  • Shaw, Karen Joy;
  • Ibrahim, Ashraf S
  • et al.
Abstract

Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after 96 h versus placebo. Changes in GM levels in BAL fluid and serum mirrored reductions in lung CE, with significant decreases seen after 96 h or 72 h for fosmanogepix or posaconazole, respectively (P < 0.02).

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