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SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.

  • Author(s): Bruzzone, Chiara;
  • Bizkarguenaga, Maider;
  • Gil-Redondo, Rubén;
  • Diercks, Tammo;
  • Arana, Eunate;
  • García de Vicuña, Aitor;
  • Seco, Marisa;
  • Bosch, Alexandre;
  • Palazón, Asís;
  • San Juan, Itxaso;
  • Laín, Ana;
  • Gil-Martínez, Jon;
  • Bernardo-Seisdedos, Ganeko;
  • Fernández-Ramos, David;
  • Lopitz-Otsoa, Fernando;
  • Embade, Nieves;
  • Lu, Shelly;
  • Mato, José M;
  • Millet, Oscar
  • et al.

COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress.

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