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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- Jostins, Luke;
- Ripke, Stephan;
- Weersma, Rinse K;
- Duerr, Richard H;
- McGovern, Dermot P;
- Hui, Ken Y;
- Lee, James C;
- Philip Schumm, L;
- Sharma, Yashoda;
- Anderson, Carl A;
- Essers, Jonah;
- Mitrovic, Mitja;
- Ning, Kaida;
- Cleynen, Isabelle;
- Theatre, Emilie;
- Spain, Sarah L;
- Raychaudhuri, Soumya;
- Goyette, Philippe;
- Wei, Zhi;
- Abraham, Clara;
- Achkar, Jean-Paul;
- Ahmad, Tariq;
- Amininejad, Leila;
- Ananthakrishnan, Ashwin N;
- Andersen, Vibeke;
- Andrews, Jane M;
- Baidoo, Leonard;
- Balschun, Tobias;
- Bampton, Peter A;
- Bitton, Alain;
- Boucher, Gabrielle;
- Brand, Stephan;
- Büning, Carsten;
- Cohain, Ariella;
- Cichon, Sven;
- D’Amato, Mauro;
- De Jong, Dirk;
- Devaney, Kathy L;
- Dubinsky, Marla;
- Edwards, Cathryn;
- Ellinghaus, David;
- Ferguson, Lynnette R;
- Franchimont, Denis;
- Fransen, Karin;
- Gearry, Richard;
- Georges, Michel;
- Gieger, Christian;
- Glas, Jürgen;
- Haritunians, Talin;
- Hart, Ailsa;
- Hawkey, Chris;
- Hedl, Matija;
- Hu, Xinli;
- Karlsen, Tom H;
- Kupcinskas, Limas;
- Kugathasan, Subra;
- Latiano, Anna;
- Laukens, Debby;
- Lawrance, Ian C;
- Lees, Charlie W;
- Louis, Edouard;
- Mahy, Gillian;
- Mansfield, John;
- Morgan, Angharad R;
- Mowat, Craig;
- Newman, William;
- Palmieri, Orazio;
- Ponsioen, Cyriel Y;
- Potocnik, Uros;
- Prescott, Natalie J;
- Regueiro, Miguel;
- Rotter, Jerome I;
- Russell, Richard K;
- Sanderson, Jeremy D;
- Sans, Miquel;
- Satsangi, Jack;
- Schreiber, Stefan;
- Simms, Lisa A;
- Sventoraityte, Jurgita;
- Targan, Stephan R;
- Taylor, Kent D;
- Tremelling, Mark;
- Verspaget, Hein W;
- De Vos, Martine;
- Wijmenga, Cisca;
- Wilson, David C;
- Winkelmann, Juliane;
- Xavier, Ramnik J;
- Zeissig, Sebastian;
- Zhang, Bin;
- Zhang, Clarence K;
- Zhao, Hongyu;
- Silverberg, Mark S;
- Annese, Vito;
- Hakonarson, Hakon;
- Brant, Steven R;
- Radford-Smith, Graham;
- Mathew, Christopher G;
- Rioux, John D;
- Schadt, Eric E;
- Daly, Mark J;
- Franke, Andre;
- Parkes, Miles;
- Vermeire, Severine;
- Barrett, Jeffrey C;
- Cho, Judy H
Published Web Location
https://doi.org/10.1038/nature11582Abstract
A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.
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