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Role of pancreatic cancer-derived exosomes in salivary biomarker development

  • Author(s): Lau, C
  • Kim, Y
  • Chia, D
  • Spielmann, N
  • Eibl, G
  • Elashoff, D
  • Wei, F
  • Lin, YL
  • Moro, A
  • Grogan, T
  • Chiang, S
  • Feinstein, E
  • Schafer, C
  • Farrell, J
  • Wong, DTW
  • et al.
Abstract

Background: Salivary biomarkers for systemic diseases have been undermined due to lack of mechanistic and biological rationale. Results: Suppression of exosome biogenesis leads to ablation of salivary biomarkers. Conclusion: Tumor-derived exosomes provide a mechanism for discriminatory biomarkers in saliva. Significance: Tumor-derived exosomes provide the scientific rationale that connects pancreatic tumors and the oral cavity leading to salivary biomarkers. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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