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Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

  • Author(s): Vilella, Laura
  • Lacuey, Nuria
  • Hampson, Johnson P
  • Rani, MR Sandhya
  • Sainju, Rup K
  • Friedman, Daniel
  • Nei, Maromi
  • Strohl, Kingman
  • Scott, Catherine
  • Gehlbach, Brian K
  • Zonjy, Bilal
  • Hupp, Norma J
  • Zaremba, Anita
  • Shafiabadi, Nassim
  • Zhao, Xiuhe
  • Reick-Mitrisin, Victoria
  • Schuele, Stephan
  • Ogren, Jennifer
  • Harper, Ronald M
  • Diehl, Beate
  • Bateman, Lisa
  • Devinsky, Orrin
  • Richerson, George B
  • Ryvlin, Philippe
  • Lhatoo, Samden D
  • et al.
Abstract

OBJECTIVE:To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. METHODS:This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed. RESULTS:We studied 148 GCS in 87 patients. Nineteen patients had generalized epilepsy; 65 had focal epilepsy; 1 had both; and the epileptogenic zone was unknown in 2. Ictal central apnea (ICA) preceded GCS in 49 of 121 (40.4%) seizures in 23 patients, all with focal epilepsy. Postconvulsive central apnea (PCCA) occurred in 31 of 140 (22.1%) seizures in 22 patients, with generalized, focal, or unknown epileptogenic zones. In 2 patients, PCCA occurred concurrently with asystole (near-SUDEP), with an incidence rate of 10.2 per 1,000 patient-years. One patient with PCCA died of probable SUDEP during follow-up, suggesting a SUDEP incidence rate 5.1 per 1,000 patient-years. No cases of laryngospasm were detected. Rhythmic muscle artifact synchronous with breathing was present in 75 of 147 seizures and related to stertorous breathing (odds ratio 3.856, 95% confidence interval 1.395-10.663, p = 0.009). CONCLUSIONS:PCCA occurred in both focal and generalized epilepsies, suggesting a different pathophysiology from ICA, which occurred only in focal epilepsy. PCCA was seen in 2 near-SUDEP cases and 1 probable SUDEP case, suggesting that this phenomenon may serve as a clinical biomarker of SUDEP. Larger studies are needed to validate this observation. Rhythmic postictal muscle artifact is suggestive of post-GCS breathing effort rather than a specific biomarker of laryngospasm.

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