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Small lipidated anti-obesity compounds derived from neuromedin U
- Micewicz, Ewa D;
- Bahattab, Omar SO;
- Willars, Gary B;
- Waring, Alan J;
- Navab, Mohamad;
- Whitelegge, Julian P;
- McBride, William H;
- Ruchala, Piotr
Published Web Location
https://doi.org/10.1016/j.ejmech.2015.07.020Abstract
A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. The most promising compound, NM4-C16 was effective in a once-weekly-dose regimen. Collectively, our findings suggest that short, lipidated analogs of NmU are suitable leads for the development of novel anti-obesity therapeutics.
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