Deep hypothermia for the treatment of refractory status epilepticus.
- Author(s): Niquet, Jerome;
- Baldwin, Roger;
- Gezalian, Michael;
- Wasterlain, Claude G
- et al.
Published Web Locationhttps://doi.org/10.1016/j.yebeh.2015.06.028
In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE. This article is part of a Special Issue entitled "Status Epilepticus".