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Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers
- Medina, Jamie E;
- Annapragada, Akshaya V;
- Lof, Pien;
- Short, Sarah;
- Bartolomucci, Adrianna L;
- Mathios, Dimitrios;
- Koul, Shashikant;
- Niknafs, Noushin;
- Noe, Michael;
- Foda, Zachariah H;
- Bruhm, Daniel C;
- Hruban, Carolyn;
- Vulpescu, Nicholas A;
- Jung, Euihye;
- Dua, Renu;
- Canzoniero, Jenna V;
- Cristiano, Stephen;
- Adleff, Vilmos;
- Symecko, Heather;
- van den Broek, Daan;
- Sokoll, Lori J;
- Baylin, Stephen B;
- Press, Michael F;
- Slamon, Dennis J;
- Konecny, Gottfried E;
- Therkildsen, Christina;
- Carvalho, Beatriz;
- Meijer, Gerrit A;
- Andersen, Claus Lindbjerg;
- Domchek, Susan M;
- Drapkin, Ronny;
- Scharpf, Robert B;
- Phallen, Jillian;
- Lok, Christine AR;
- Velculescu, Victor E
Published Web Location
https://doi.org/10.1158/2159-8290.cd-24-0393Abstract
SIGNIFICANCE: There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.
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