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“Blueberry muffin” rash and large right thigh mass: a unique presentation of Langerhans cell histiocytosis

  • Author(s): Lau, Erica G
  • Stepenaskie, Shelly
  • Moran, Rebecca
  • Quinn, Robert
  • Matthew, Prasad
  • Smidt, Aimee C
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Langerhans cell histiocytosis (LCH) is a clonal proliferation of bone marrow derived antigen-presenting cells that can involve a spectrum of cutaneous findings, with or without internal organ involvement. Neonatal LCH almost always presents with skin findings, usually petechial papules and/or erosions in a seborrheic distribution, with or without extracutaneous involvement. Previously described as varying entities, LCH is now considered a single disease process demonstrating a spectrum of clinical findings. We report a unique case of neonatal LCH presenting with a “blueberry muffin” rash in conjunction with a large soft tissue tumor.

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