Public Health & Health Science Division, ULAB

Castleman Disease is a rare disorder in which a person experiences an overgrowth of cells in the lymph nodes. Research on Castleman Disease is, at the moment, very elementary due to the lack of patient population size and previous research. Currently, the only research on Castleman disease covers understanding classifications of the disorder, possible causes ranging from immune deficiencies to cytokines, and genetics (Jiang et al., 2020). Because of the disease’s rarity, scientists have not conducted much research; thus, there is still no cure for this disease, and its cause is largely unknown. We analyzed research publications from sources such as PubMed, Google Scholar, and NIH. This paper will study the development of Castleman Disease in relation to the interplay between genetic and epidemiological factors, as evidenced by the associations between Castleman Disease and specific DNA mutations, HIV, and HHV-8.