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Enhancer redundancy provides phenotypic robustness in mammalian development
- Osterwalder, Marco;
- Barozzi, Iros;
- Tissières, Virginie;
- Fukuda-Yuzawa, Yoko;
- Mannion, Brandon J;
- Afzal, Sarah Y;
- Lee, Elizabeth A;
- Zhu, Yiwen;
- Plajzer-Frick, Ingrid;
- Pickle, Catherine S;
- Kato, Momoe;
- Garvin, Tyler H;
- Pham, Quan T;
- Harrington, Anne N;
- Akiyama, Jennifer A;
- Afzal, Veena;
- Lopez-Rios, Javier;
- Dickel, Diane E;
- Visel, Axel;
- Pennacchio, Len A
Published Web Location
https://doi.org/10.1038/nature25461Abstract
Gene enhancer knockout phenotypes and analysis of enhancer activity patterns show that developmental genes are regulated by multiple redundant enhancers in mouse embryos.
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