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IgM ocular cicatricial pemphigoid: a unique insight into the immune system

  • Author(s): Tazudeen, Noor
  • Au, Sonoa
  • Pewitt, Jonathan
  • Tu, Elmer
  • Aronson, Iris K
  • et al.
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License
Abstract

A 42-year-old man with ocular erythema and scarring had a conjunctival biopsy revealing depostion of IgM and C3 without IgG at the epithelial basement membrane zone.  Treatment with doxycyline, dapsone, and mycophenolate mofetil was unsuccessful and treatment with rituximab has led to partial remission of the conjunctival inflammation. He has undergone 4 cycles of rituximab treatment at intervals of 12 to 18 months.

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