Schnitzler syndrome in a patient with a family history of monoclonal gammopathy
- Author(s): Wilmas, Kelly
- Aria, Alexander
- Torres-Cabala, Carlos A
- Lu, Huifang
- Duvic, Madeleine
- et al.
Published Web Locationhttps://doi.org/10.5070/D3241037926
Schnitzler syndrome is a rare disease characterized by chronic urticaria and a monoclonal gammopathy, most commonly IgM with light chains of the kappa type. There are currently no known risk factorsassociated with development of the disease. We report a case of Schnitzler syndrome in a 48-year-old man with a family history of monoclonal gammopathies. The patient’s disease has been well controlled with anakinra therapy. Our case may contribute to a better understanding of the etiology of Schnitzler syndrome as his history could suggest a hereditarypredisposition for the disease. Further studies are necessary to determine whether a genetic component of Schnitzler syndrome exists, as first-degree relatives of patients with monoclonal gammopathies may be at risk for the development of the disease.