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Open Access Publications from the University of California

Novel, Post-Translationally Modified Peptide Antibiotics from Solitary Tunicates

  • Author(s): Lehrer, Robert I.
  • et al.

The goal of this research project was to elucidate the structures of antimicrobial peptides from the tunicates Styela clava, S. plicata and Ciona intestinalis. These three species of primitive-looking organisms are simple protochordate ancestors of the vertebrates and thrive in microbe-laden shallow waters of Southern California. Because of this, researchers have long speculated these organisms must have effective and robust immune systems.

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