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Open Access Publications from the University of California

Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

  • Author(s): Baek, JH
  • Rubinstein, M
  • Scheuer, T
  • Trimmer, JS
  • et al.

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Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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