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Advances in Deep Neuropathological Phenotyping of Alzheimer’s disease: Past, Present, and Future
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Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized pathologically by the presence of neurofibrillary tangles (NFTs) and amyloid beta aggregates in the brain. It was first described in 1906 by Alois Alzheimer, and it is currently the most common cause of dementia worldwide. This paper delves into the past, present, and future outlook for AD, focusing on historical microscopy & staining advancements, disease heterogeneity, and improved neuropathological phenotyping through the use of machine learning.