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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
- Parvatiyar, Kislay;
- Zhang, Zhiqiang;
- Teles, Rosane M;
- Ouyang, Songying;
- Jiang, Yan;
- Iyer, Shankar S;
- Zaver, Shivam A;
- Schenk, Mirjam;
- Zeng, Shang;
- Zhong, Wenwan;
- Liu, Zhi-Jie;
- Modlin, Robert L;
- Liu, Yong-jun;
- Cheng, Genhong
Published Web Location
https://doi.org/10.1038/ni.2460Abstract
Activation of type I interferon by c-di-GMP and c-di-AMP depends on the adaptor STING. Cheng and colleagues show that these bacterial secondary messengers are detected by the helicase DDX41, which forms a complex with STING.
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