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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
- Paşca, Anca M;
- Sloan, Steven A;
- Clarke, Laura E;
- Tian, Yuan;
- Makinson, Christopher D;
- Huber, Nina;
- Kim, Chul Hoon;
- Park, Jin-Young;
- O'Rourke, Nancy A;
- Nguyen, Khoa D;
- Smith, Stephen J;
- Huguenard, John R;
- Geschwind, Daniel H;
- Barres, Ben A;
- Paşca, Sergiu P
Published Web Location
https://doi.org/10.1038/nmeth.3415Abstract
A method for 3D differentiation of human pluripotent stem cells yields brain cortical spheroids with functional neurons and astrocytes. The spheroids can be sliced for imaging and electrophysiological studies.
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