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Open Access Publications from the University of California

Signet-ring squamous cell carcinoma: a report of a rare variant and review of the literature

  • Author(s): Haghayeghi, Koorosh
  • Telang, Gladys
  • Robinson-Bostom, Leslie
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Signet-ring squamous cell carcinoma is a rare histological subtype of squamous cell carcinoma. The distinct morphologic appearance of this variant can mimic metastatic adenocarcinoma and impose a diagnostic challenge. Unlike its glandular counterpart, signet-ring cell variant of squamous cell carcinoma has a poorly characterized histopathogenesis with no known prognostic implication. We describe an additional case and review the literature.

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