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Targeted genome editing across species using ZFNs and TALENs.

  • Author(s): Wood, Andrew J
  • Lo, Te-Wen
  • Zeitler, Bryan
  • Pickle, Catherine S
  • Ralston, Edward J
  • Lee, Andrew H
  • Amora, Rainier
  • Miller, Jeffrey C
  • Leung, Elo
  • Meng, Xiangdong
  • Zhang, Lei
  • Rebar, Edward J
  • Gregory, Philip D
  • Urnov, Fyodor D
  • Meyer, Barbara J
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489282/
No data is associated with this publication.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.

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