Dermatology Online Journal
Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumab
- Author(s): Reddick, CL
- Singh, MN
- Chalmers, RJG
- et al.
Letter: Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumabThe Dermatology Centre, University of Manchester, Salford Royal Foundation Hospital, Manchester, UK
CL Reddick, MN Singh, RJG Chalmers
Dermatology Online Journal 16 (8): 15
Pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS) are chronic inflammatory dermatoses that can be a challenge to treat. A role for TNF-alpha in their pathogenesis has been postulated in the literature. A therapeutic benefit of infliximab has been reported in recalcitrant cases of both conditions. To date, there is less evidence about the use of adalimumab for these conditions. We report a patient with severe superficial PG on a background of HS, which responded to adalumimab therapy after failure of infliximab therapy.
Pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS) are both chronic inflammatory dermatoses. Infliximab has been shown to be of therapeutic benefit in recalcitrant cases of both conditions and a role for TNF-alpha in their pathogenesis has thus been proposed [1, 2, 3, 4]. To date, there is less evidence for the use of adalimumab for these conditions. We report a patient with severe superficial PG on a background of HS, which responded to adalumimab therapy after failure of infliximab therapy.
|Figure 1a||Figure 1b|
|Figure 1a. Vegetating plaques of superficial pyoderma gangrenosum|
Figure 1b. After eleven months of adalumimab, 40mg given subcutaneously, fortnightly.
A 54-year-old man presented to our service with an eighteen month history of painful, ulcerating and vegetating plaques on his trunk and limbs consistent clinically with a diagnosis of superficial PG (Figure 1a). He complained of boils in the axillae, groin, and buttocks since his teenage years resulting in quite marked scarring consistent with HS (Figure 2). Investigations for alternative causes of pyoderma gangrenosum included full blood count, liver function tests, immunoglobulins, autoantibodies, and chest x-ray, all of which were within normal limits. Culture of a skin swab yielded no significant growth of organisms. Endoscopic investigation for inflammatory bowel disease was negative. A skin biopsy was consistent with the clinical diagnosis and revealed a dense acute and chronic dermal inflammatory infiltrate with scattered small giant cell granulomata and areas of ulceration and abscess formation (Figure 3). Ziehl-Neelsen and PAS stains were negative.
|Figure 2||Figure 3|
|Figure 2. Chronic scarring from hidradenitis suppurativa of the buttocks|
Figure 3. Skin biopsy (H+E) with a dense acute and chronic inflammatory infiltrate and small granulomata (x10)
Prior treatment included high dose oral corticosteroids, prednisolone (40 mg daily) and dapsone (100 mg daily), with the later addition of cyclosporine (2.5 - 4 mg/kg). Reduction in dose of these produced flares of his condition. Significant improvement was seen following acceptance into an open pilot study of infliximab (two infusions at 5 mg/kg) for PG. However, further funding was not available for continuation of treatment. A poor response to pulsed intravenous methylprednisolone followed by thalidomide (100 mg/200 mg) necessitated reintroduction of oral prednisolone. This was continued at 10 mg daily in conjunction with cyclosporine (2.5 mg/kg) and minocycline (100 mg bd).
The latter regimen was moderately effective for eighteen months until minocycline was discontinued because of marked skin dyspigmentation. The dose of cyclosporine was tapered gradually and withdrawn. Within three months his PG flared severely; extensive new vegetating plaques developed resulting in a major impact on his quality of life (Dermatology Life Quality Index [DLQI] score 20/30) . A further trial of infliximab resulted in significant infusion reactions after two doses. Funding on compassionate grounds was successfully obtained for adalimumab (80mg week 1, 40 mg week 2, 40 mg fortnightly thereafter). Significant improvement was noted at three weeks and his skin was clear of active inflammation by twelve weeks; a dramatic improvement in DLQI score (4/30) was achieved. He remains on fortnightly injections of adalimumab with no adverse effects detected. The PG has remained quiescent on this therapy for eleven months (Figure 1b), although he has had a mild flare of his HS. Minocycline has been reinstituted with good effect.
Superficial PG is an uncommon variant of classical PG that shows superficially ulcerated and vegetative plaques . There is a characteristic, although not pathognomic, appearance of focal neutrophilic abcesses in the papillary dermis with peripheral palisaded histiocytes and giant cells. This variant is said to be relatively benign and more responsive to treatment than classical PG, but evidence for this assertion is not completely convincing , as illustrated by our patient.
The coexistence of PG and HS has been reported [8, 9] but the frequency of association with the superficial subtype is unknown. There is a significant body of literature to support the use of infliximab in resistant cases of both conditions [1, 2, 3, 4]. Response for treatment periods up to twelve months has been reported with PG and up to six months with HS. This suggests a common pathogenetic factor with a significant role for the cytokine TNF-alpha in the development of these diseases. However clinical benefit has been limited by funding problems, infusion reactions or loss of efficacy. As a consequence, alternative biological agents have been used. In HS, a good response to adalimumab response (40 mg fortnightly) has been noted within one month and maintained up to a mean period of 21 months . We are aware of six reports of benefit from adalimumab in patients with PG [6, 7, 12, 13, 14]. In four patients infliximab therapy had not sustained disease remission prior to initiating adalimumab. Three patients had co-existent inflammatory bowel disease. Significant improvement occurred within 8 to 12 weeks of commencing adalimumab (loading dose 80 mg, thereafter 40 - 80 mg/fortnightly). Therapy duration at time of publication ranged from four to six months. There were no adverse effects described in these reports or in our case. Our experience accords with published case reports and supports the consideration of adalimumab as an alternative to infliximab in the management of recalcitrant pyoderma gangrenosum. Our case also demonstrates that benefit from continued therapy may be maintained for longer than has been reported in previous cases. Further reports will help to establish the true value of adalimumab for this unpleasant disease.
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